abstract：:Mechanical forces applied to cultured bone cells induce the production of cAMP via stimulation of the formation of prostaglandin E2 (PGE2) and its release into the medium, resulting in stimulation of adenylate cyclase. In this paper we show that either the antibiotic gentamycin (100 micrograms/ml) or antiphospholipid ...

journal_title：Calcified tissue international

authors： Binderman I,Zor U,Kaye AM,Shimshoni Z,Harell A,Sömjen D

更新日期：1988-04-01 00:00:00

abstract：:The method of heat-denaturation and trypsin digestion was used to dissect bone biochemically into mineral-protected and mineral-unprotected pools of collagenous matrix. It was found that varying the particle size of the bone powder had a profound effect on the results. Using mature bovine cortical bone, the observed p...

journal_title：Calcified tissue international

authors： Wu JJ,Eyre DR

更新日期：1988-04-01 00:00:00

abstract：:The presence of lipids in urinary stones was determined by histochemical and biochemical methods. When crystals of calcium oxalate, made by mixing calcium chloride and potassium oxalate solutions and sections of human calcium oxalate urinary stones, were exposed to osmium vapors, there was no staining of the pure crys...

journal_title：Calcified tissue international

authors： Khan SR,Shevock PN,Hackett RL

更新日期：1988-02-01 00:00:00

abstract：:Proteoglycans are recognized to inhibit calcium pyrophosphate dihydrate (CPPD) crystal formation but the mechanisms are not known. To study the role of carboxylate (-CO2-) ligands, the possible inhibitor effects of sodium acetate, sodium D-glucuronate, disodium malate, and trisodium citrate were studied using solution...

journal_title：Calcified tissue international

authors： Cheng PT,Pritzker KP

更新日期：1988-01-01 00:00:00

abstract：:Conventional glucocorticoids exert a negative influence on calcium balance, and long-term treatment with these agents leads to osteopenia. Deflazacort is an oxazoline derivative of prednisolone with documented calcium-sparing properties when compared to prednisone on a weight basis. The purpose of the present study wa...

journal_title：Calcified tissue international

authors： Lund B,Egsmose C,Jørgensen S,Krogsgaard MR

更新日期：1987-12-01 00:00:00

abstract：:Patients put at bedrest for medical reasons lose 1-2% of spinal bone mineral per week. Losses of this magnitude during even short-term space flights of a few months would pose a serious limitation and require countermeasures. The spinal bone mineral (L2-L4) was determined in 6 healthy males (precision = 2%) before and...

journal_title：Calcified tissue international

authors： LeBlanc A,Schneider V,Krebs J,Evans H,Jhingran S,Johnson P

更新日期：1987-11-01 00:00:00

abstract：:The mineral of cortical bones has been studied in newborn, growing, and adult rats and in the calf and cow, using X-ray diffraction and infrared spectroscopy during the thermal decomposition of bones and by microassay of carbonate. The mineral of all the bone samples, regardless of species or age, was found to be a ca...

journal_title：Calcified tissue international

authors： Legros R,Balmain N,Bonel G

更新日期：1987-09-01 00:00:00

abstract：:The present study reports on the separation of fluid from soft, "cheeselike" enamel of porcine permanent teeth in the secretory stage, and the determination of its chemical composition. The enamel tissues were dissected from mandibles of 5 to 6-month-old piglets and pooled under mineral oil in centrifuge tubes, and th...

journal_title：Calcified tissue international

authors： Aoba T,Moreno EC

更新日期：1987-08-01 00:00:00

abstract：:Aluminum ions (Al) and chromium (III) ions (Cr), as they exist in aqueous solution at neutral pH, adsorb onto calcium hydroxyapatite crystals (HAP) and severely inhibit their dissolution process, when present in concentrations less than 1 microM. Iron (III) ions (Fe), at concentrations up to 10 microM, have no effect ...

journal_title：Calcified tissue international

authors： Christoffersen MR,Thyregod HC,Christoffersen J

更新日期：1987-07-01 00:00:00

abstract：:Thyroxine (T4), triiodothyronine (T3), and alkaline phosphatase (AP) were assayed monthly in white-tailed deer plasma obtained from the antler (A), jugular (J), and the saphenous (S) veins during the period of antler growth and the period of mineralization. The concentrations of T3, T4, and AP in the J and S were not ...

journal_title：Calcified tissue international

authors： Bubenik GA,Sempere AJ,Hamr J

更新日期：1987-07-01 00:00:00

abstract：:The aim of the investigation was to measure the effect of fluoride on vertebral trabecular bone compressive strength and to correlate this with fluoride-induced changes in bone density. This correlation would express changes in the quality of bone during fluoride treatment. Pigs were used in the experiment because the...

journal_title：Calcified tissue international

authors： Mosekilde L,Kragstrup J,Richards A

更新日期：1987-06-01 00:00:00

abstract：:Periodic fringes corresponding to six different lattice planes have been observed in apatite crystals of human normal alveolar bone by transmission electron microscopy. Three of these sets of fringes have spacings less than 3.5 A corresponding to the Scherzer resolution of the microscope used. The (0002) lattice plane...

journal_title：Calcified tissue international

authors： Cuisinier F,Bres EF,Hemmerle J,Voegel JC,Frank RM

更新日期：1987-06-01 00:00:00

abstract：:Gallium nitrate (GaN) reduces cancer-related hypercalcemia and inhibits bone resorption in vitro. This study investigated the effects of chronic GaN administration on bone, kidney, and parathyroid gland activity of growing rats. Experimental animals received GaN (1.75 mg elemental gallium i.p. QOD X 8, Ga+), and contr...

journal_title：Calcified tissue international

authors： Cournot-Witmer G,Bourdeau A,Lieberherr M,Thil CL,Plachot JJ,Enault G,Bourdon R,Balsan S

更新日期：1987-05-01 00:00:00

abstract：:To experimentally examine the participation of amelogenins in controlled mineral-phase maturation of mammalian enamel, the identification of the individual proteins and their corresponding gene(s) is required. For this purpose, cDNAs were constructed from polyadenylated RNA from 2-day postnatal murine teeth, molecular...

journal_title：Calcified tissue international

authors： Lau EC,Bessem CC,Slavkin HC,Zeichner-David M,Snead ML

更新日期：1987-04-01 00:00:00

abstract：:Histomorphometric evaluation of bone formation in an intravital tetracycline-labeled skeleton of a suddenly deceased osteoporotic woman is presented. The 24 skeletal sites investigated displayed substantial regional variations which, for two out of four cortical bone dynamics and all trabecular bone dynamics, were sig...

journal_title：Calcified tissue international

authors： Pødenphant J,Engel U

更新日期：1987-04-01 00:00:00

abstract：:The calcium ion binding properties of a high molecular weight bovine phosphophoryn preparation have been studied at high ionic strength (0.5 M KCl as supporting electrolyte). Surprisingly, even under these conditions at which intermolecular ionic interactions are effectively screened, phosphophoryn was capable of bind...

journal_title：Calcified tissue international

authors： Stetler-Stevenson WG,Veis A

更新日期：1987-02-01 00:00:00

abstract：:Mandibular first molars of 17-day-old mouse embryos were cultured in vitro to examine the histological effects of various concentrations of parathyroid hormone (PTH) on odontogenesis of the molars. PTH did not affect the cytodifferentiation of mesenchymal cells into preodontoblasts but inhibited that of preodontoblast...

journal_title：Calcified tissue international

authors： Sakakura Y

更新日期：1987-01-01 00:00:00

abstract：:We carried out a clinical trial of 1 alpha-hydroxycholecalciferol [1 alpha(OH)D3] at a dose of 1.0 microgram a day on 7 patients with psoriasis vulgaris. These patients had been treated by topical applications of corticosteroids before this study without improvement, and during the clinical trial, treatment of topical...

journal_title：Calcified tissue international

authors： Takamoto S,Onishi T,Morimoto S,Imanaka S,Yukawa S,Kozuka T,Kitano Y,Seino Y,Kumahara Y

更新日期：1986-12-01 00:00:00

abstract：:Radioiodination of synthetic human 37-49 osteocalcin requires optimal labeling conditions in order to obtain a maximum of mono- and di-iodinated tracer with little contamination by tri- and tetra-iodinated products or "radio-damage." The antibody raised against osteocalcin(h37-49) had the highest affinity for the C-te...

journal_title：Calcified tissue international

authors： Jüppner H,Schettler T,Giebel G,Wenner S,Hesch RD

更新日期：1986-11-01 00:00:00

abstract：:Mandibular first molars from 17-day-old mouse embryos were cultivated in vitro for 10 days using a new organ culture method. This method consisted of using a small glass dish and an agar chamber to slowly float the molars to the gas-medium interface where they were maintained by the surface tension of the medium. The ...

journal_title：Calcified tissue international

authors： Sakakura Y

更新日期：1986-10-01 00:00:00

abstract：:Alkaline phosphatase is detected in both soluble and particulate fractions of rat bone. The concentration of alkaline phosphatase in the particulate fraction of rat skull cap bone and femur is high during the peak period of calcification of these bones suggesting the possibility of using it as a marker for the rate of...

journal_title：Calcified tissue international

authors： Murthy GP,Rajalakshmi R,Ramakrishnan CV

更新日期：1986-09-01 00:00:00

abstract：:This study examines the efficacy of using radiolabeled thymidine as a measure of bone cell DNA synthesis. The effect of a bone-active peptide on cell proliferation is assessed under different labeling conditions and it is shown that the apparent stimulation in DNA synthesis is due to an increase in participating cells...

journal_title：Calcified tissue international

authors： Puzas JE,Brand JS

更新日期：1986-08-01 00:00:00

abstract：:In order to study in detail the processes leading to the resorption and ankylosis of teeth after trauma, the effects of cold application on the periodontal tissues were studied in the mouse. Liquid nitrogen was applied locally to the outer surface of the lower jaw which resulted in a freezing of the incisor and its su...

journal_title：Calcified tissue international

authors： Wesselink PR,Beertsen W,Everts V

更新日期：1986-07-01 00:00:00

abstract：:To investigate the possible role of calmodulin in the calcium sensitivity of parathyroid adenylate cyclase (AC), the effect of the calmodulin inhibitor trifluoperazine hydrochloride (TFP) on the calcium sensitivity of forskolin-stimulated AC activity was investigated in membranes prepared from normal porcine parathyro...

journal_title：Calcified tissue international

authors： Oldham SB,Lipson LG

更新日期：1986-05-01 00:00:00

abstract：:Enamel of intact human teeth laser irradiated in vitro under certain conditions is known to have less subsurface demineralization than unirradiated enamel on exposure to acid; consequently, the potential use of laser irradiance to reduce caries is apparent. The laser-induced physical and/or chemical changes that cause...

journal_title：Calcified tissue international

authors： Fowler BO,Kuroda S

更新日期：1986-04-01 00:00:00

abstract：:The purpose of this study was to determine whether total serum calcium, parathyroid gland structure, and/or levels of parathyroid hormone, 1,25 and 24,25 DHCC, are altered in pigs with dental and skeletal fluorosis. Eight experimental animals receiving 2 mg F-/kg b.w. per day from age 8-14 months were compared with ei...

journal_title：Calcified tissue international

authors： Andersen L,Richards A,Care AD,Andersen HM,Kragstrup J,Fejerskov O

更新日期：1986-04-01 00:00:00

abstract：:Twenty boys were followed during their puberty for about 2 years with examinations every third month. At each examination we determined serum concentrations of 25OHD3, 1,25(OH)2D3, 24,25(OH)2D3, 25.26(OH)2D3, alkaline phosphatase (AP) and testosterone together with bone mineral content (BMC) at the distal forearm. Hig...

journal_title：Calcified tissue international

authors： Krabbe S,Christiansen C,Hummer L

更新日期：1986-03-01 00:00:00

abstract：:There is increasing evidence that 1,25 dihydroxyvitamin D3 acts directly to differentiate and activate cells of mononuclear phagocyte lineage (MNP). However, it seems possible that in bone marrow this hormone may modulate the differentiation of MNP via the factor elaborated by the stromal cells or the macrophages. We ...

journal_title：Calcified tissue international

authors： Nakamura T,Araki K,Kanda S,Kurisu K

更新日期：1986-01-01 00:00:00

abstract：:We compared indices of three-dimensional microstructure of iliac trabecular bone between 26 patients with vertebral compression fractures due to postmenopausal osteoporosis and 24 control subjects without vertebral fracture, who were matched for age, sex, race, menopausal status, and several densitometric and histolog...

journal_title：Calcified tissue international

authors： Kleerekoper M,Villanueva AR,Stanciu J,Rao DS,Parfitt AM

更新日期：1985-12-01 00:00:00

abstract：:Changes in the acidity of osteoclasts were evaluated by direct measurement of the fluorescent intensity of osteoclasts exposed to acridine orange, a fluorescent weak base which becomes concentrated in acid-containing subcellular compartments. Parathyroid hormone (PTH) produced dose-dependent increases in fluorescent i...

journal_title：Calcified tissue international

authors： Anderson RE,Jee WS,Woodbury DM

更新日期：1985-12-01 00:00:00

abstract：:At 4 and 24 hours after injection of (35S)sulfate, there were 22-67% fewer silver grains on conventionally fixed sections than on sections fixed by cryotechniques. Differences were smaller when (3H) glucosamine was chosen as precursor. The number of silver grains increased between 4 and 24 hours in predentine and in a...

journal_title：Calcified tissue international

authors： Goldberg M,Escaig F

更新日期：1985-09-01 00:00:00

abstract：:1,25 Dihydroxyvitamin D3 (1,25(OH)2D3) (2.0 micrograms) was given intramuscularly to 6 healthy adult males. Twenty-four circadian patterns of blood-ionized calcium (Ca2+), serum phosphate (Pi), and total calcium (CaT) were assessed pre- and posthormone administration. Correlations of mean mineral rhythms with normativ...

journal_title：Calcified tissue international

authors： Markowitz ME,Rosen JF,Mizruchi M

更新日期：1985-07-01 00:00:00

abstract：:Employing a cytochemical bioassay, we compared parathyroid function in normal and X-linked hypophosphatemic (Hyp) mice. Under basal conditions Hyp mice manifested hypocalcemia and, in accord, had a plasma bioactive parathyroid hormone concentration (3.04 +/- 0.14 pg/ml) significantly greater than that of normals (2.16...

journal_title：Calcified tissue international

authors： Posillico JT,Lobaugh B,Muhlbaier LH,Drezner MK

更新日期：1985-07-01 00:00:00

abstract：:The effect of parathormone (PTH), lipopolysaccharide (LPS), or interleukin-1 (IL-1) on calcium release and collagen degradation in bone was examined in vitro using labeled neonatal calvaria of normal mice and also of osteopetrotic microphthalmic (mi/mi) mice that have defective osteoclasts. All three agents stimulated...

journal_title：Calcified tissue international

authors： Jilka RL,Hamilton JW

更新日期：1985-05-01 00:00:00

abstract：:Conventional transmission electron microscopy requires an effective dehydration of the tissue specimens under investigation. This dehydration, for which ethanol most often is used, may influence the solubility of the slightly soluble calcium phosphates. To study the behavior of calcium phosphates in ethanol, stable ne...

journal_title：Calcified tissue international

authors： Larsen MJ,Thorsen A,Jensen SJ

更新日期：1985-03-01 00:00:00

abstract：:Vitamin K promotes the formation of gamma-carboxylated glutamate (GLA) in several protein species. GLA residues have a high affinity for the Ca ion. In the present study, we tested the hypothesis that experimental vitamin K deficiency in rats could induce changes in Ca metabolism. Vitamin K depletion, which was associ...

journal_title：Calcified tissue international

authors： Robert D,Jorgetti V,Lacour B,Leclerq M,Cournot-Witmer G,Ulmann A,Drüeke T

更新日期：1985-03-01 00:00:00

abstract：:In 11 postmenopausal women with histologically proven osteoporosis and normal lactose tolerance, a direct correlation between calcium absorption and intestinal lactase activity was observed. The results suggest that varying degrees of relative deficiencies in intestinal lactase might contribute to the graded decrease ...

journal_title：Calcified tissue international

authors： Pacifici R,Droke D,Avioli LV

更新日期：1985-01-01 00:00:00

abstract：:Mononuclear phagocytes have been implicated as important cellular elements in the process of bone resorption. We have postulated that the recruitment and migration of mononuclear phagocytes to bone occurs via a mechanism(s) in which bone-derived chemotactic factors (BDCF) are released from foci undergoing resorption. ...

journal_title：Calcified tissue international

authors： Minkin C,Bannon DJ Jr,Pokress S

更新日期：1985-01-01 00:00:00

abstract：:Two rheumatic syndromes associated with deposition of calcium phosphate crystals in soft tissues of the shoulder have prompted us to study the cellular mechanisms of calcium phosphate crystal solubilization. Synthetic 45Ca labeled calcium phosphate crystal aggregates were solubilized by cultured human fibroblasts or m...

journal_title：Calcified tissue international

authors： Evans RW,Cheung HS,McCarty DJ

更新日期：1984-12-01 00:00:00

abstract：:ATP is as effective as inorganic pyrophosphate in retarding the rate of dissolution of calcium hydroxyapatite at pH 7, ADP is less effective, and AMP is without effect. The inhibition is due to the adsorption of ATP and ADP units on the crystal surface. ...

journal_title：Calcified tissue international

authors： Christoffersen MR,Christoffersen J

更新日期：1984-12-01 00:00:00